一、網傳影片出自美國媒體電視節目，該節目邀請一名醫藥記者分析新冠疫苗第四劑。該記者先介紹一篇醫學研究，研究指出接種第四劑後抗體會明顯增加，但抗體持續多久不清楚。
她隨後個人評論，建議民眾「低估打越多劑、抗體越高」說法，她略提到「免疫也可能開始關閉」，但她並未提出證據，也沒有多做解釋。
二、查核中心協請台灣感染症和免疫學專家檢視影片，專家們表示，網傳影片有關「關閉免疫系統」的說法，指的是免疫耐受性，這是指反覆暴露在相同抗原下，可能讓免疫系統對此抗原疲乏，對免疫反應的刺激變得不明顯。
三、專家說，目前無證據顯示，新冠疫苗打多了會有免疫耐受性的問題，且接種新冠疫苗並不會影響免疫系統對其他疾病抗原的免疫力，未發生網傳所提「關閉免疫系統」現象。
傳言把記者個人意見的描述，錯誤指稱為「電視台承認」，因此，為「錯誤」訊息。
【補充資料】
❗根據衛福部在2022年7月21日更新的文件，對於新冠疫苗第二次追加劑（第四劑）的建議為：
以下對象建議接種
65歲以上長者
長照機構住民
18歲以上免疫不全及免疫力低下且病情穩定者，包括：目前正進行或1年內曾接受免疫抑制治療之癌症患者、器官移植患者/幹細胞移植患者、中度/嚴重先天性免疫不全患者、洗腎患者、HIV陽性患者、目前正使用高度免疫抑制藥物者、過去6個月內接受化學治療或放射線治療者、其他經醫師評估因免疫不全或免疫力低下，可接種基礎加強劑者
開放下列對象可評估自身染疫風險與意願接種
醫事人員(包含醫事執登人員及醫事機構非醫事人員)
機場港埠、居家檢疫相關工作人員及航空機組員/船員
機構與社福照護系統相關工作人員
50-64歲成人
18歲以上因外交、公務、洽商等工作需求需出國者
❗網傳影片醫療記者 Jennifer Ashton 的發言原文如下：
Yes, you got some new data on boosters. There's a new published study out in Lancet, the journal Lancet infectious disease about the fourth dose. And what happens to our antibody levels, it is not a surprise that they've released new data confirming that after the fourth dose of Pfizer, or Maderna, that antibody levels rise significantly, they surge in the several weeks after that dose. We've known that for a while.
But here are the caveats. We don't know how long that lasts. Number one, and our immune response, remember, is not just about antibodies, it's about that T cell response also, which is you can't really measure as well as just a pure antibody level.
And it's about whether or not they're blocking or neutralizing antibodies to the variant that we're seeing. So when people hear these headlines, they shouldn't be surprised. Yes, of course, you're going to get a surge in your antibody levels. But how long that lasts is the issue.
And it's certainly not just about more boosting for everyone, people who have high antibody levels, there's the potential, I want to underscore the potential we haven't seen any evidence of this, of this immune phenomenon known as tolerance, where if you already have high antibody levels, and you get another booster, that your immune system can start to say, Well, what what am I needed for and can kind of start to shut down.
So we, if you're in that category of people who the FDA and CDC is recommending to get a booster 50 and over 65 and over with a chronic medical condition? Yes, by all means, but everyone else don't think that more boosting is the answer. We don't know that. That's the case.
